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The fact that much of the research has been published by a relatively small number of teams, often in less demanding journals and without sufficient independent replication is definitely concerning. That said, he adds, there have been a few studies published outside of Croatia that report broadly similar findings, which is somewhat reassuring, though still not definitive

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86 In fact, due to the overlap of phenotypes and growing understanding of intersecting biology, it remains controversial that the definition and boundary between syndromic and idiopathic ASD