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1,2 The IGFBPs may modulate the action of IGFs in several different ways: Inhibitory Model - IGFBPs prevent IGF/receptor association Enhancing Model - IGFBPs transport IGFs and facilitate binding with IGF receptors IGF Receptor-Independent Model - Product of direct IGFBPs/IGFBP receptor interaction Proteolytic Cleavage of IGFBP - Cleaved into lower affinity fragments which increases freely circulating, bioavailable IGF IGF-1 IGF-1 (Somatomedin C) is one of several growth factors necessary for normal human development
94 HuD.SunX.MagpusaoA.FedorovY.ThompsonM.WangB.et al (2021)
In general, there is no evidence that TNF inhibitors impact either the safety or the efficacy of other vaccines, although live vaccines should be avoided
