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9:00 - ASSAY DEVELOPMENT FOR PYRUVATE DEHYDROGENASE KINASE INHIBITOR DISCOVERY Nathan Lilla University of Nebraska at Kearney Pyruvate dehydrogenase kinase (PDK) regulates the activity of the pyruvate dehydrogenase complex (PDC) by phosphorylating its E1 subunit, thereby limiting conversion of pyruvate to acetyl-CoA, restricting entry into the TCA cycle, and reducing ATP production