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Research indicates that colonizing adult GF mice with a conventional microbiota significantly elevates their serum IGF-1 levels, correlating with heightened levels of the bone formation marker P1NP (N-terminal propeptide of type I collagen) and elevated bone formation rates, thereby facilitating both radial and longitudinal bone growth

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Involvement of occupational therapy helps with transitioning to independence in areas such as self-care and performing other activities of daily living