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Animal studies have also demonstrated that Rag1 knockout mice, which lack mature T and B cells, show reduced Ang II-induced salt-sensitive hypertension [229, 233]

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Perioperative considerations With their superiority in glycaemic control, low incidence of fasting hypoglycaemia, roles in weight management, and established evidence for their cardiovascular benefits, GLP-1 agonists present as highly attractive agents in improving patient outcomes in the perioperative setting, with growing interest for these agents to be continued without perioperative interruption