Medications like Ozempic, Wegovy, and other injectables have gained popularity as treatments for diabetes, obesity, and other weight-related ailments or conditions
In another recent publication (126), it was shown that pretreatment with the dual-GLP-1/GIP receptor agonist DA3-CH or liraglutide could decrease the levels of ERS damage proteins (CHOP, GRP78,) and pro-apoptotic factors (Bax, Caspase12) as well as increase anti-apoptotic factor (Bcl-2), and reduce neuronal death and neurological damage after stroke in diabetic rats
It is possible that this relatively selective colonic mucosal involvement may reflect the qualitative or quantitative differences in colonic microbial flora (as opposed to the small intestine)
Ein langsamer Spaziergang, der mit Fettsuren betrieben wird, braucht dagegen zu viel Zeit und setzt zu viele Stresshormone frei, um effizient zu sein