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Safety and pharmacokinetics of single and multiple ascending doses of the novel oral human GLP-1 analogue, oral semaglutide, in healthy subjects and subjects with type 2 diabetes

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Compounds and standards were captured by a biotinylated monoclonal anti-human IgG1 antibody at 100 g/mL (in-house) and detected by an Alexa-labelled monoclonal anti-human IgG1 antibody at 10 nM (The Binding Site) on a Gyrolab Bioaffy 200 CD platform (Gyros AB)

A.Martnez-BotasJ.Martn-SnchezC.BustoR.Gmez-CoronadoD