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For people with compromised immune systems, cancerous cells can develop in as few as five years

[2] As of 2022, the Japanese adult smoking rate was 14.8%

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In the Panels assessment of the increase in MPLA, it found that this alternative eliminates the ability of tobacco companies to sell their products to people under the age of 21 years and competitive opportunities associated with such sales.[17] Based on evidence, the Panel found that this would reduce the overall volume of imports of tobacco products commensurate with that of the TPP measures.[18] While it also reduces the overall value of imports, the evidence did not allow an assumption that the reduction in the value of imports would be less than what was observed with the TPP measures.[19] Regarding increase in taxation, the Panel found that this measure would have an equal impact on the overall consumption of tobacco products and is therefore as trade-restrictive as the TPP measures.[20] Therefore, the Panel concluded that both these alternative measures were not less trade-restrictive than the TPP measures