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Kromer A, Moosmann B

Figure 2 Previous studies found that pro-inflammatory cytokines, including tumor necrosis factor- (TNF-) and interleukin (IL)-6, IL-1, and C-reactive protein (CRP), are markedly increased in the blood and CSF of patients with depression (Hestad et al., 2016

the reduced lateral diffusion of GLP-1R V229A could therefore be due to the mutant receptor existing as a subpopulation of pre-clustered, higher order oligomeric assemblies in absence of agonist stimulation, predicted to cause a decrease in the movement of these clusters and potentially hinder cholesterol binding