Importantly, it enabled discrimination between human-specific and animal-specific toxicities, such as those induced by bosentan (an endothelin receptor antagonist with known dose-dependent human hepatotoxicity) and fialuridine (an antiviral nucleoside analog that caused fatal human liver toxicity undetected in animals), thereby improving the extrapolation of preclinical findings to human outcomes
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Epilepsy Res 106(12):5463 de Souza AG, Chaves Filho AJM, Souza Oliveira JV, de Souza DAA, Lopes IS, de Carvalho MAJ, de Lima KA, Floreno Sousa FC, Mendes Vasconcelos SM, Macedo D (2019) and M
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