glutathione for hair growth before and after redox cycle. Glutathione (GSH) is synthesized from the Glutathione Redox Cycle Infographic With

A meta-analytic summary of systemic GSH indicates variable doseresponse and inconsistent biomarker effects, complicating mechanistic attribution

doi: 10.1007/s10571-020-00960-w 48 HarrisonB

MASH resolution without worsening of fibrosis: 2.4 mg dose: 47% of participants (vs 14% placebo) 4.8 mg dose: 62% of participants (vs 14% placebo) 6.0 mg dose: 43% of participants (vs 14% placebo) Liver fat reduction of at least 30%: 2.4 mg dose: 63% of participants 4.8 mg dose: 67% of participants 6.0 mg dose: 57% of participants Placebo: 14% of participants Fibrosis improvement by at least one stage: Survodutide groups: 34-36% Placebo: 22% The percentage change from baseline in liver fat content after 48 weeks was a staggering 62% reduction in the 6.0 mg group, compared to just 5.7% in the placebo group

However, studies were conducted in Asian populations with significantly darker baseline skin tones (Fitzpatrick IVVI), effects were not permanent, and outcomes were variable one included trial found no significant change