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Containing MST in tea bag-like sachets overcame what USSTs smoker focus groups identified as the top barriers deterring them from continuing traditional MST use after receiving free samples: (1) the messiness of float (strands of tobacco in the mouth), (2) the lipburn from tobacco sitting directly on the gum and lip, and (3) user anxiety over ascertaining the optimal size of pinch [22]

Excessive alcohol consumption, particularly when combined with tobacco, further raises the risk

Nicotine is inactivated by a healthy liver and its metabolites are excreted in the urine

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