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These modifications have been hypothesized to play a crucial role in the diffusion of DNA damage response/senescence-associated secretory phenotype (DDR/SAPS) signaling to non-damaged surrounding cells during aging, suggesting that DDR/SASP signaling components may contribute to the development of novel therapeutic interventions against age-related diseases (Olivieri et al., 2015)

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Conditions associated with subnormal 5-NT levels Lead poisoning Lead exposure can lead to subnormal levels of 5-NT due to direct inhibitory effects on the enzyme in serum 120,121 and red blood cells