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That dissociation is the strongest practical argument for treating cerebrospinal fluid and plasma markers in these trials as exploratory readouts of target engagement rather than as stand-ins for benefit

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However, it should be kept in mind that although this review discusses NAD + status and concentrations, the terminologies and interpretations are nuanced and complex because 1 ) there is no consensus standard as to high compared with adequate compared with low NAD + levels with respect to concentrations that impact cell-specific pathways

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