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In a short 2021 trial, people who stopped semaglutide after 20 weeks regained most of their lost weight after almost a year but still ended up about 4 percent below their starting weight

This provides a buffer so the vial does not touch the ice pack directly, which prevents accidental freezing

The dose relationships used in clinical practice come from indirect comparisons, primarily the SURPASS-2 trial data and accumulated clinical experience

Jacqueline Maya , a pediatric endocrinologist and physician-investigator at Massachusetts General Hospital who studies how events in pregnancy impact the health of both mother and child