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As a microbicide, bile leads to bacterial oxidative stress and the ROS production in the gallbladder

M.RaravikarK.LiuJ.et al (2015)

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(This also explains why aqueous-solubility models outperformed intrinsic-solubility models on the intrinsic-solubility test sets.) Nevertheless, using to predict pH-dependent solubility gives a good qualitative match with experiment, excepting cases where ion aggregation leads to lower-than-expected solubility