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24,25 Leptin responsive neurons in the ARC include those containing the agouti-related peptide (AgRP) and orexigenic peptides neuropeptide Y (NPY), and those containing the anorexigenic peptides -melanocyte-stimulating hormone (-MSH) and cocaine and amphetamine-regulated transcript (CART)

Coordinated pathological changes include fibrosis, stromal stiffening, and myofibroblast expansion in both compartments, which compromise joint biomechanics and serve as sources of persistent nociceptive signaling (Tang et al., 2024

Leaves the skin looking clearer, firmer, and more even