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Using sermorelin while on pegvisomant raises GH pulses that cannot produce IGF-1 feedback, risking prolonged GH excess

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The transition does not require a washout period most clinicians simply stop one and start the other

A case report published in Physiological Reports (PMID 36303408) documented that co-administration of MK-677 and LGD-4033 in a 25-year-old male produced measurable increases in lean body mass (+3.1% trunk lean) alongside significant lipid and hepatic biomarker disruption, underscoring the importance of controlled research conditions when investigating sustained GHS-R1a stimulation