Bottom line: High-quality, transparently sourced supplements are easier on your vital organs because they don't introduce extra waste for your body to process
Introduction Free copper accumulation in many tissues (liver, brain, cornea, joints) also known as hepatolenticular degeneration mutation in ATP7B results in free copper generates free radicals that damage tissues see Metabolism of copper topic AR inheritance Presentation Symptoms Parkinson-like symptoms hemiballismus dementia Physical exam cirrhosis corneal deposits on slit lamp examination Evaluation total serum copper serum non-ceruloplasmin bound copper urine/serum free copper hemolytic anemia Liver Biopsy If performed will show increased hepatic copper Treatment Medical ammonium tetrathiomolybdate trientine zinc Surgical Consider liver transplantation as clinical condition deteriorates Prognosis, Prevention, and Complications At risk for liver disease hepatitis cirrhosis carcinoma (hepatocellular) Also at risk for Fanconi's disease of the proximal tubules
Changes to mobility If left untreated, B12 deficiency can damage the nervous system and affect balance and coordination, even leading to changes in walking and movement
James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K et al (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
