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[11] Two other meta-analyses reported a similar decrease in relative risk

Siri-Tarino PW, Williams PT, Fernstrom HS, Rawlings RS, Krauss RM

Snapshot Proponents Effective for L-carnitine deficiency Supports mitochondrial health and energy function Allegedly supports liver and brain health May improve PCOS in women and semen quality and fertility in men Skeptics Many popular uses are not supported by evidence May contribute to heart disease by metabolizing TMAO Can cause nausea or stomach upset Long-term use may cause oxidative stress in the liver and blood Affects thyroid function Health Benefits of Carnitine Effective for: L-Carnitine Deficiency (Genetic) Oral and intravenous L-carnitine is effective for the treatment of primary and secondary L-carnitine deficiency due to inborn errors of metabolism (genetic)

Specifically, zinc-deficient neurons exhibited moderate membrane potential depolarization, reduced cell capacitance, increased afterhyperpolarization, shortened burst duration, and accelerated spike frequency adaptation