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Heavier cannabis users did not fare quite so well in the long-term, as lifetime FEV 1 gains levelled off or even reversed with increased exposure

According to Wang (2023) in Adderall Dosage: How Much Is Too Much? misuse by exceeding prescribed doses also raises the risk of dependency and overdose, with overdose symptoms such as restlessness, tremors, confusion, and cardiovascular complications

Release of tumor necrosis factor-alpha from human alveolar macrophages is decreased in smokers