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"The dose was fairly directly related to the amount of chronic sinusitis that people developed," says David Arnold, M.D., a professor of otolaryngology at the University of Miami Miller School of Medicine

In fact, its nicotine content is one of the highest among e-cigarettes on the market

Mitchell et al's 23 cross-sectional survey of 12- to 17-year-old never smokers found that all of the different standardized packs shown were consistently rated as harmful, with no significant differences in ratings between standardized packs with different structures

Everyone remembers what they were doing the day Kennedy was shot