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Poplawski, G

The DMFA methodology is widely used when the parasitized blood source is obtained directly from a patient and when the experiment can be performed within a few hours ( ex vivo ookinete transformation assay, we performed the SMFA in which the drug is incubated with the parasites, and, subsequently, these are used to carry out membrane feeding of the anophelines

For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

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