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This trend is in contrast to the rxYFP fusion constructs with mono- and dithiol variants of ScGrx1, which were shown to react more rapidly with GSSG when the second cysteinyl residue was replaced by serine (Table 1) 31

Accumulation of ethanol-associated reactive molecules, e.g., reactive oxygen (ROS) and nitrogen species (RNS), and electrophilic products, e.g., acetaldehyde and lipid peroxidation-derived products, can be harmful to biological systems due to their propensity to inactivate enzymes, leading to loss of protein function, DNA damage and cell death 4

These findings were subsequently also confirmed in Type 2 DM (DM2) (108)

Similar to other chronic conditions like heart disease or asthma, the treatment goal for SUD is typically not a radical cure but rather managing it as a chronic condition through a combination of complementary methods (12)