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At low temperature, electron transport chains tend to form O2-, which dismutates to form H2O2

Begliuomini S, Casarosa E, Pluchino N, Lenzi E, Centofanti M, Freschi L, et al

This leads to a reduction in ovarian reserve and a higher occurrence of chromosomal abnormalities especially aneuploidy in oocytes 3,4 , increasing the risks of infertility, pregnancy loss, perinatal mortality, and congenital disorders in women at an advanced age 5,6

RSL3 stimulation elevated C3, IL-1, and TNF- levels in mixed glial cultures, while the ferroptosis inhibitor liproxstatin-1 effectively attenuated RSL3-induced neurotoxicity, supporting a role for ferroptotic stress in promoting neurotoxic glial activation