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In each group, we extracted risk factors using the method described in Section 2.4 and Section 2.5

Estrogen is known to decrease serum uric acid levels by promoting uric acid excretion through reduction of post-secretory tubular reabsorption of uric acid 30 , and by decreasing uric acid production through inhibition of the activity of xanthine oxidase 31

Finally, the reliance on self-reported data, rather than biomarkers, to assess SHS exposure may compromise the objectivity, and our US-based findings may have limited applicability to countries with different cultural backgrounds, smoking regulations, and healthcare systems