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Dr Shendy Engelina Consultant Dermatologist and Clinical Service Lead at Dermatica

In a similar rat model, Mazo et al., 2013 [17] showed that the administration of SNAC at 1.4 mg/kg daily by gavage for 8 weeks could reduce the collagen-occupied area associated with an upregulation of matrix metalloproteinases-13 and -9 and a downregulation of heat-shock protein-60, tissue inhibitors of metalloproteinase-2, TGF-1, and collagen-1

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Progressing too fast Related to starting too high, progressing too quickly through concentration levels doesn't allow skin adequate time to adapt