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Overall, mast cells have 50 200 granules in the cytoplasm of the cell, storing histamine, heparin, tryptase, cytokines, etc.[ref] The image below shows mast cell (stained purple) degranulation under a microscope.[ref] Allergies: Activating mast cells by Type 1 hypersensitivity In addition to reacting to antigens on pathogens, such as bacteria, the IgE can also be primed to link with antigens on proteins that are not pathogens, referred to as allergens

For other serious unexpected adverse drug reactions, Korean regulations typically require notification within 7 days, with a full report within 15 days analogous to EUs SUSAR reporting timelines, but sponsors cannot assume that reporting to EudraVigilance or the EMA alone suffices

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