Long-Acting GHRH Analog : Unlike natural GHRH, which has a short duration of action, CJC-1295 has been modified to bind to a receptor in the pituitary gland and stimulate growth hormone release continuously
A few report mild breakouts or increased oiliness, especially without concurrent vitamin C use
The incorporation of various unnatural amino acid residues into peptides was proven to be a very productive methodology
Nonetheless, it is important to highlight the high heterogeneity and limitations of the studies, such as (1) low to moderate methodological quality, (2) variation in a selected population, (3) a lack of inclusion and evaluation in different skin types, (4) small sample sizes, (5) variable designs, (6) types of chemical peels, (7) deficient efficacy measures, (8) short-term or no follow-up, (9) attrition rate, (10) heterogeneities in the grouped results, and (11) poor conclusions