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10.1007/s10787-022-01099-4 3 BeckerM

Although being commonly known as Jaboski diagram, the more correct name of this model is the Perrin-Jaboski diagram (after Jean Baptiste Perrin (18701942), Francis Perrin (19011992), and Aleksander Jaboski (18981980)) modified by Alexander N

The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

It crosses the cell membrane and translocates to the nucleus under metabolic stress, where it regulates nuclear gene expression tied to glucose metabolism and oxidative capacity